Polynucleotides are an advanced injectable treatment designed to improve skin quality, hydration, elasticity and overall skin health. Unlike dermal fillers, polynucleotides work by supporting tissue repair and collagen stimulation to improve the condition of the skin itself.
This treatment is ideal for patients seeking natural-looking skin rejuvenation without adding volume or changing facial structure.
Polynucleotides are advanced regenerative injectable treatments designed to improve skin quality, hydration and elasticity while supporting the skin’s natural repair processes.
They are composed of highly purified DNA fragments, commonly derived from salmon or trout, which are carefully processed for use in aesthetic medicine. Polynucleotides work by stimulating cellular repair, supporting collagen production and improving hydration within the skin.
Unlike dermal fillers, polynucleotides do not primarily add volume. Instead, they focus on improving overall skin quality and supporting natural-looking skin rejuvenation.
Improves skin texture
Enhances hydration
Supports collagen stimulation
Improves skin elasticity
Reduces crepey skin
Helps tired or dull-looking skin
Improves under-eye skin quality
Helps brighten tired-looking under eyes
May improve the appearance of under-eye dark circles
Supports natural skin regeneration
Under Eyes
Polynucleotides are commonly used for under-eye rejuvenation to improve:
Fine lines
Crepey skin
Thin under-eye skin
Tired-looking eyes
Skin texture
Face
Improves overall skin quality, hydration and texture while supporting a fresher appearance.
Neck
Helps improve crepey skin and skin laxity.
Décolletage
Improves ageing and sun-damaged skin across the chest area.
Hands
Supports skin rejuvenation and hydration in ageing hands.
Treatment Duration
Approximately 15 minutes + numbing time
Sessions Recommended
Typically 3–4 sessions spaced 2–4 weeks apart
Downtime
Minimal to none
Results
Visible within weeks, with optimal results developing over approximately 2 months
Duration
Approximately 6–9 months
Maintenance
Recommended every 4–6 months
Price
From £250
Polynucleotides
Dermal Fillers
Improve skin quality
Restore lost volume
Stimulate regeneration
Add structure and contour
Natural skin rejuvenation
Facial shaping and contouring
Focus on skin health
Focus on volume replacement
Many patients combine both treatments as part of a comprehensive facial rejuvenation plan.
We offer advanced polynucleotide treatments tailored to the treatment area and skin concern. Polynucleotides may be used to improve skin quality, hydration and collagen stimulation across delicate and ageing areas.
Treatment plans are personalised following consultation.
Most patients require a course of 3–4 treatments spaced approximately 2–4 weeks apart, depending on the treatment area, skin condition and individual concerns.
Maintenance treatments are typically recommended every 4–6 months to help maintain results and support ongoing skin quality improvement.
A consultation is carried out before treatment to assess suitability and discuss your concerns and goals.
Polynucleotides are carefully injected into the treatment area using precise injection techniques. Treatment usually takes approximately 15 minutes, excluding numbing time.
You may experience temporary:
Mild swelling
Redness
Small injection-point bumps
Tenderness
Bruising
These effects usually settle within several days.
Full aftercare advice will be provided following treatment.
Frequently Asked Questions
Polynucleotide treatments have become increasingly popular due to their regenerative approach to skin rejuvenation. Unlike treatments that primarily add volume, polynucleotides focus on improving skin quality, hydration, elasticity and collagen stimulation. Many patients choose polynucleotides for natural-looking improvement in under-eye skin quality, fine lines and overall skin health.
Polynucleotides are regenerative injectable treatments designed to improve skin quality, hydration and elasticity while supporting the skin’s natural repair processes.
Polynucleotides work by stimulating cellular repair, supporting collagen production and improving hydration within the skin.
No. Dermal fillers are designed to restore volume and contour, whereas polynucleotides focus on improving skin quality and regeneration.
Common treatment areas include the under eyes, face, neck, décolletage and hands.
Yes. Polynucleotides are commonly used to improve under-eye skin quality, fine lines and crepey skin.
Polynucleotides may help improve the appearance of some under-eye dark circles by improving skin quality, hydration and skin thickness.
Yes. Polynucleotides are commonly used to improve crepey, thin and dehydrated skin.
Most patients require a course of 3–4 treatments spaced approximately 3–4 weeks apart, depending on the treatment area and skin condition.
Treatment usually takes approximately 15 minutes excluding numbing time.
Results develop gradually over several weeks, with optimal results typically seen after approximately 2 months.
Results typically last approximately 6–9 months, although this varies between individuals.
Downtime is usually minimal. Mild swelling, redness, bruising or small injection-point bumps may occur temporarily.
Most patients tolerate treatment well. A topical numbing cream may be used to improve comfort during treatment.
Temporary swelling, redness, bruising and tenderness may occur following treatment.
Yes. Polynucleotides are commonly combined with anti-wrinkle injections, skin boosters, microneedling and dermal fillers where appropriate.
Skin boosters primarily focus on hydration, whereas polynucleotides focus on regeneration, tissue repair and collagen stimulation in addition to hydration support.
Tear trough filler restores lost volume under the eyes, whereas polynucleotides focus on improving under-eye skin quality and texture.
Polynucleotides are widely used in aesthetic medicine and are considered safe when administered by a qualified medical professional following consultation.
Polynucleotide treatment may be suitable for patients seeking improvement in skin quality, hydration, fine lines and overall skin rejuvenation.
Treatment may not be suitable during pregnancy or breastfeeding, or for patients with certain medical conditions. Suitability is assessed during consultation.
Polynucleotides are commonly derived from highly purified salmon or trout DNA that has been carefully processed for medical use.
Polynucleotides may help improve certain mild textural irregularities and acne scarring by supporting skin regeneration.
Polynucleotides may help improve skin elasticity and skin quality, although they are not a replacement for surgical lifting procedures.
Yes. Polynucleotides support collagen production as part of the skin regeneration process.
Yes. Polynucleotides may help improve dull, dehydrated and tired-looking skin by improving hydration and skin quality.
Maintenance treatments are commonly recommended every 4–6 months depending on the individual and treatment area.
Patients are usually advised to avoid excessive heat, strenuous exercise, alcohol and makeup application for a short period after treatment.
Patients are generally advised to avoid makeup for approximately 24 hours after treatment unless otherwise advised by their practitioner.
Polynucleotides may be preferred when the primary concern is skin quality, hydration and regeneration rather than volume loss.
Book a Consultation
If you would like to find out whether polynucleotide treatment is suitable for you, please contact the clinic to arrange a consultation.